Coevolution of the California Ground Squirrel and the Northern Pacific Rattlesnake

Snake venom evolved to kill specific squirrels
with shocking precision
Kaplan, Sarah . Weblog post. Washington Post – Blogs , Washington: WP Company LLC d/b/a The

Washington Post. May 20, 2016.

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In high school biology, you learned that co-evolution was an arms race. Gazelles speed up to escape cheetahs,

who grow ever-swifter as the generations pass. Crabs grow more powerful claws to puncture snails’ thicker and

thicker shells. Every living thing on Earth is engaged in a battle to become bigger, safer, deadlier, smarter, faster,

harder to track and more difficult to evade.

But evolution is not always an all-out war. Sometimes it’s more subtle — an ever-evolving negotiation between two

species that are constantly sizing up one another, seeking out vulnerabilities and adjusting their strategies in

response to what they find. It’s diplomatic. Except instead of concluding with peace, these negotiations end when

one animal eats the other. (Let’s not share this metaphor with anyone at the United Nations.)

Take, for example, the rattlesnakes and squirrels of northern California, combatants in a notoriously bitter conflict

that has raged over centuries. Each species is armed to the teeth (literally). Squirrels team up to mob their

rattlesnake predators, ward them off with bushy tails, and even chew up snake skin and rub it on their fur to

confuse snakes trying to sniff them out (which is so meta). Snakes, meanwhile, perfect stealthy slithers and

possess heat-sensing pits on their faces, not to mention incredibly toxic venom.

But, as is fitting for a savvy snake, a rattler uses its chief weapon as a scalpel, not a sledgehammer. A study

published this week in the journal Proceedings of the Royal Society B found that California rattlesnakes’ venom is

carefully calibrated to overcome the specific defenses raised by the squirrels in their region. As a result, the venom

varies measurably from county to county, possibly even from one highway exit to the next. California snake venom

is kind of like wine — it comes in regional varieties. None of which you want to be drinking.

The battle starts at birth, when squirrels begin creating anti-venom proteins that they pump into their blood stream,

arming themselves for the day when a rattlesnake attacks. These proteins vary based on the environment —

altitude, annual rainfall, type of vegetation — and on the venom of the snakes that live in the region.

[These bugs have a startling strategy for keeping predators away]

In response, the snakes are constantly tweaking the composition of their own venom, working on ways to

overcome those defenses.

“It’s like a lock and a key,” said Matthew Holding, an evolutionary ecologist at Ohio State University and the lead

author of the study. “Resistance is a lock and venom is the key and I have to have the right key to open the door.”

This process isn’t a conscious one; it’s a product of natural selection. Squirrels with inadequate defenses get eaten

before they can pass their wimpy genes down to their children. Likewise, snakes with unsuitable venom starve to

death before they can reproduce. Those that do live are the ones best suited for battle.

And at the moment, the snakes seem to have the upper hand, Holding said. When he and his colleagues tested 12

venoms from 12 different regions against 12 squirrel blood samples from those same areas, the venoms usually

beat out the blood from their same region. These fights were staged in test tubes, but it’s simple to imagine what

they mean for the real world: lots of dead squirrels.

[Fine feathers: Why red birds look so fit and sexy]

That’s surprising, Holding said, because most theories of evolutionary biology predict that prey’s defenses should

be marginally better than their predator’s weapons. Prey, after all, have more to lose.

“It’s a longstanding idea called the Life-Dinner principle,” Holding said. “If the predator loses in a given contest it

just misses a meal. But if the prey loses it dies.”

Natural selection should work more intensely on those that avoid dying than ones who simply manage to get

dinner, he continued. But the snake venom study suggests that something more complex may go down when two

species co-evolve.

It’s important that we understand how this works — and not just because it’s interesting to evolutionary biologists

(or because we feel bad for squirrels). Venomous snakes bite several thousand people a year in the United States,

and every year a few of those people die. Doctors, pharmaceutical companies and ophidiophobes would all like to

know more about variation in snake venom and ways of protecting against it.

“It’s a complex and fascinating system with lots of other questions to ask,” Holding said.

Read more:

How did the giraffe get its improbable neck? Genetic analysis finds some clues.

Lady spiders demand gifts from their gentleman callers — or else they eat them

Listening for love: How female crickets got so good at hearing their mates

Scientists pinpoint the genes that give Darwin’s finches their distinct beaks


Publication title: Washington Post – Blogs; Washington

Publication year: 2016

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Publication date: May 20, 2016

Section: Speaking Of Science

Publisher: WP Company LLC d/b/a The Washington Post

Place of publication: Washington

Country of publication: United States, Washington

Publication subject: General Interest Periodicals–United States

Source type: Blogs, Podcasts, &Websites

Language of publication: English

Document type: Blogs

ProQuest document ID: 1790144987

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Copyright: Copyright WP Company LLC d/b/a The Washington Post May 20, 2016

Last updated: 2018-10-08

Database: U.S. Newsstream,%20Sarah&rft.aulast=Kaplan&rft.aufirst=Sarah&

Snake venom evolved to kill specific squirrels with shocking precision

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